Amarogentin

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Selleck Chemicals

S1273-5MG

€146,00 EUR
€146,00 EUR
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Amarogentin is an agonist of TNF-alpha and AMPK used in studies of PI3K-Akt-mTOR Signaling and NF-kB Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and inflammatory transcriptional control and stress-responsive survival signaling in apoptosis, autophagy, and cancer models.

By activating TNF-alpha and AMPK, Amarogentin can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TNF-alpha and AMPK
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and NF-kB Signaling and related signaling programs
  • Agonist-response and downstream signaling studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, Amarogentin is appropriate when a defined chemical perturbant is needed to connect TNF-alpha and AMPK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TNF-alpha • AMPK
Target Class:
Immunomodulator
Pathways:
PI3K-Akt-mTOR Signaling • NF-kB Signaling • Immune Signaling
Research Area:
Apoptosis • Autophagy • Cancer • Cell Cycle
CAS No.:
21018-84-8
Molecular Weight:
586.54
Formula:
C₂₉H₃₀O₁₃
SMILES:
OCC1OC(OC2OC=C3C(CCOC3=O)C2C=C)C(OC(=O)C4=C(O)C=C(O)C=C4C5=CC=CC(=C5)O)C(O)C1O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.