AMG-900

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Selleck Chemicals

S2719-5MG

€167,00 EUR
€167,00 EUR
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AMG-900 is an inhibitor of Aurora Kinases and AURKA and related targets used in studies of JAK-STAT Signaling and Cell Cycle Regulation. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation and checkpoint control, mitotic progression, and proliferation timing in cancer, cell cycle, and cell signaling models.

By inhibiting Aurora Kinases and AURKA and related targets, AMG-900 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and checkpoint control, mitotic progression, and proliferation timing. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell cycle, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Aurora Kinases and AURKA and related targets
  • Pathway perturbation studies connected to JAK-STAT Signaling and Cell Cycle Regulation
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, AMG-900 is appropriate when a defined chemical perturbant is needed to connect Aurora Kinases and AURKA and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell cycle, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Aurora Kinases • AURKA • AURKB • AURKC
Target Class:
Kinase
Pathways:
JAK-STAT Signaling • Cell Cycle Regulation
Research Area:
Cancer • Cell Cycle • Cell Signaling
CAS No.:
945595-80-2
Molecular Weight:
503.58
Formula:
C₂₈H₂₁N₇OS
SMILES:
CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.