Ataluren (PTC124)

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Selleck Chemicals

S6003-10MG

€144,00 EUR
€144,00 EUR
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Ataluren (PTC124) is an inhibitor of CFTR used in studies of ion-channel pharmacology. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to ion conductance, membrane potential, and electrophysiological responses in cell signaling models.

By inhibiting CFTR, Ataluren (PTC124) can be used to examine ion conductance, membrane potential, and electrophysiological responses. This target class is commonly examined through electrophysiology, ion-flux, and membrane-potential studies, together with downstream-response mapping. In cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving CFTR
  • Concentration-response inhibition and target-dependence studies
  • Electrophysiology, ion-flux, and membrane-potential studies
  • Phenotypic profiling in cell signaling models

Overall, Ataluren (PTC124) is appropriate when a defined chemical perturbant is needed to connect CFTR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
CFTR
Target Class:
Ion Channel
Research Area:
Cell Signaling
CAS No.:
775304-57-9
Molecular Weight:
284.24
Formula:
C₁₅H₉FN₂O₃
SMILES:
C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F
InChIKey:
OOUGLTULBSNHNF-UHFFFAOYSA-N
PubChem:
11219835
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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