Atorvastatin Calcium (CI-981)

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Selleck Chemicals

S2077-50MG

€144,00 EUR
€144,00 EUR
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Atorvastatin Calcium (CI-981) is an inhibitor of HMG-CoA Reductase used in studies of Apoptosis and Autophagy and related signaling programs. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation in apoptosis, autophagy, and cancer models.

By inhibiting HMG-CoA Reductase, Atorvastatin Calcium (CI-981) can be used to examine caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HMG-CoA Reductase
  • Pathway perturbation studies connected to Apoptosis and Autophagy and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, Atorvastatin Calcium (CI-981) is appropriate when a defined chemical perturbant is needed to connect HMG-CoA Reductase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HMG-CoA Reductase
Target Class:
Enzyme
Pathways:
Apoptosis • Autophagy • Metabolic Signaling
Research Area:
Apoptosis • Autophagy • Cancer • Cardiovascular
CAS No.:
134523-03-8
Molecular Weight:
1155.34
Formula:
2(C₃₃H₃₄FN₂O₅)·Ca
SMILES:
CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.[Ca+2]
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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