Atractyloside potassium salt

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Selleck Chemicals

SKU:S3264-1MG

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Atractyloside potassium salt is an inhibitor of ATR used in studies of DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage / repair models.

By inhibiting ATR, Atractyloside potassium salt can be used to examine checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving ATR
  • Pathway perturbation studies connected to DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Atractyloside potassium salt is appropriate when a defined chemical perturbant is needed to connect ATR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
ATR
Target Class:
Kinase
Pathways:
DNA Damage Response
Research Area:
Cancer • Cell Signaling • DNA Damage / Repair
CAS No.:
102130-43-8
Molecular Weight:
802.99
Formula:
C₃₀H₄₄K₂O₁₆S₂
SMILES:
[K+].[K+].CC(C)CC(=O)OC1C(OC2CC(C3CCC45CC(CCC4C3(C)C2)C(=C)C5O)C(O)=O)OC(CO)C(O[S]([O-])(=O)=O)C1O[S]([O-])(=O)=O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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