AZ32

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Selleck Chemicals

S8729-5MG

€144,00 EUR
€144,00 EUR
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AZ32 is an inhibitor of ATM and ATR used in studies of DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage / repair models.

By inhibiting ATM and ATR, AZ32 can be used to examine checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving ATM and ATR
  • Pathway perturbation studies connected to DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, AZ32 is appropriate when a defined chemical perturbant is needed to connect ATM and ATR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
ATM • ATR
Target Class:
Kinase
Pathways:
DNA Damage Response
Research Area:
Cancer • Cell Signaling • DNA Damage / Repair
CAS No.:
2288709-96-4
Molecular Weight:
328.37
Formula:
C₂₀H₁₆N₄O
SMILES:
CNC(=O)C1=CC=C(C=C1)C2=CN=C3C=NC(=C[N]23)C4=CC=CC=C4
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.