AZD1390

1 1

Selleck Chemicals

S8680-2MG

€144,00 EUR
€144,00 EUR
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AZD1390 is an inhibitor of ATM and ATR used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage / repair models.

By inhibiting ATM and ATR, AZD1390 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving ATM and ATR
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, AZD1390 is appropriate when a defined chemical perturbant is needed to connect ATM and ATR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
ATM • ATR
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • DNA Damage Response
Research Area:
Cancer • Cell Signaling • DNA Damage / Repair
CAS No.:
2089288-03-7
Molecular Weight:
477.57
Formula:
C₂₇H₃₂FN₅O₂
SMILES:
CC(C)N1C2=C(C=NC3=CC(=C(C=C32)C4=CN=C(C=C4)OCCCN5CCCCC5)F)N(C1=O)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.