Belizatinib (TSR-011)
Selleck Chemicals
SKU:S8511-5MG
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Belizatinib (TSR-011) is an inhibitor of ALK and Trk Receptors used in studies of MAPK / ERK Signaling. It is especially relevant in cancer, cell signaling, and neuroscience models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling.
By inhibiting ALK and Trk Receptors, Belizatinib (TSR-011) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and neuroscience models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving ALK and Trk Receptors
- Pathway perturbation studies connected to MAPK / ERK Signaling
- Concentration-response inhibition and target-dependence studies
- Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
Overall, Belizatinib (TSR-011) is appropriate when a defined chemical perturbant is needed to connect ALK and Trk Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and neuroscience models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- ALK • Trk Receptors
- Target Class:
- Kinase
- Pathways:
- MAPK / ERK Signaling
- Research Area:
- Cancer • Cell Signaling • Neuroscience
- CAS No.:
- 1357920-84-3
- Molecular Weight:
- 577.73
- Formula:
- C₃₃H₄₄FN₅O₃
- SMILES:
- CC(C)NC(=O)C1CCC(CC1)N2C3=C(C=CC(=C3)CN4CCC(CC4)C(C)(C)O)N=C2NC(=O)C5=CC=C(C=C5)F
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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