BGT226 (NVP-BGT226)maleate

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Selleck Chemicals

S2749-5MG

€265,00 EUR
€265,00 EUR
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BGT226 (NVP-BGT226)maleate is an inhibitor of PI3K beta and PI3K gamma and related targets used in studies of PI3K-Akt-mTOR Signaling and Autophagy. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and autophagic flux, lysosomal turnover, and stress adaptation in autophagy, cancer, and cell signaling models.

By inhibiting PI3K beta and PI3K gamma and related targets, BGT226 (NVP-BGT226)maleate can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and autophagic flux, lysosomal turnover, and stress adaptation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PI3K beta and PI3K gamma and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and Autophagy
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, BGT226 (NVP-BGT226)maleate is appropriate when a defined chemical perturbant is needed to connect PI3K beta and PI3K gamma and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PI3K beta • PI3K gamma • MTOR • PI3K alpha
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • Autophagy
Research Area:
Autophagy • Cancer • Cell Signaling • Immunology
CAS No.:
1245537-68-1
Molecular Weight:
650.6
Formula:
C₂₈H₂₅F₃N₆O₂·C₄H₄O
SMILES:
CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=CC(=O)O)C(=O)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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