BH3I-1

1 1

Selleck Chemicals

S8177-5MG

€95,00 EUR
€95,00 EUR
Sold out
Shipping calculated at checkout.
Supplier
Size
View full details

BH3I-1 is an inhibitor of BCL-2 and p53 and related targets used in studies of Apoptosis. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions in apoptosis, cancer, and cell cycle models.

By inhibiting BCL-2 and p53 and related targets, BH3I-1 can be used to examine caspase-associated cell-death signaling and survival decisions. This context is compatible with apoptosis, viability, and caspase-readout assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving BCL-2 and p53 and related targets
  • Pathway perturbation studies connected to Apoptosis
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in apoptosis, cancer, and cell cycle models

Overall, BH3I-1 is appropriate when a defined chemical perturbant is needed to connect BCL-2 and p53 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
BCL-2 • p53 • MDM2
Target Class:
Other
Pathways:
Apoptosis
Research Area:
Apoptosis • Cancer • Cell Cycle
CAS No.:
300817-68-9
Molecular Weight:
400.31
Formula:
C₁₅H₁₄BrNO₃S₂
SMILES:
CC(C)C(C(=O)O)N1C(=O)C(=CC2=CC=C(C=C2)Br)SC1=S
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
Products may be subject to intellectual property rights.

The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.