BIBF 1120 (Nintedanib)

1 1

Selleck Chemicals

S1010-5MG

€173,00 EUR
€173,00 EUR
Sale Sold out
Taxes included. Shipping calculated at checkout.
Size
View full details

BIBF 1120 (Nintedanib) is an inhibitor of PDGFR and VEGFR and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in angiogenesis, cancer, and cell signaling models.

By inhibiting PDGFR and VEGFR and related targets, BIBF 1120 (Nintedanib) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PDGFR and VEGFR and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, BIBF 1120 (Nintedanib) is appropriate when a defined chemical perturbant is needed to connect PDGFR and VEGFR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PDGFR • VEGFR • FLT3 • FGFR1
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling
Research Area:
Angiogenesis • Cancer • Cell Signaling
CAS No.:
656247-17-5
Molecular Weight:
539.62
Formula:
C₃₁H₃₃N₅O₄
SMILES:
CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
InChIKey:
CPMDPSXJELVGJG-UHFFFAOYSA-N
PubChem:
9809715
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
Products may be subject to intellectual property rights.

The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.