BMS-833923

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Selleck Chemicals

S7138-10MG

€95,00 EUR
€95,00 EUR
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BMS-833923 is an antagonist of Hedgehog used in studies of Hedgehog Signaling and GPCR Signaling. It is especially relevant in cancer and developmental biology models, where defined compound exposure can be linked to morphogen-dependent developmental signaling and transcriptional patterning and receptor-driven second-messenger signaling and desensitization dynamics.

By blocking Hedgehog, BMS-833923 can be used to examine morphogen-dependent developmental signaling and transcriptional patterning and receptor-driven second-messenger signaling and desensitization dynamics. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Hedgehog
  • Pathway perturbation studies connected to Hedgehog Signaling and GPCR Signaling
  • Receptor-blockade and ligand-competition studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, BMS-833923 is appropriate when a defined chemical perturbant is needed to connect Hedgehog with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Hedgehog
Target Class:
Signaling Pathway Modulator
Pathways:
Hedgehog Signaling • GPCR Signaling
Research Area:
Cancer • Developmental Biology
CAS No.:
1059734-66-5
Molecular Weight:
473.57
Formula:
C₃₀H₂₇N₅O
SMILES:
CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5
InChIKey:
KLRRGBHZCJLIEL-UHFFFAOYSA-N
PubChem:
57662985
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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