BMS-986299

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Selleck Chemicals

S9899-5MG

€156,00 EUR
€156,00 EUR
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BMS-986299 is an agonist of NLRP3 used in studies of NF-kB Signaling and Immune Signaling. It is especially relevant in immunology and inflammation models, where defined compound exposure can be linked to inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses.

By activating NLRP3, BMS-986299 can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving NLRP3
  • Pathway perturbation studies connected to NF-kB Signaling and Immune Signaling
  • Agonist-response and downstream signaling studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, BMS-986299 is appropriate when a defined chemical perturbant is needed to connect NLRP3 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
NLRP3
Target Class:
Immunomodulator
Pathways:
NF-kB Signaling • Immune Signaling
Research Area:
Immunology • Inflammation
CAS No.:
2242952-69-6
Molecular Weight:
349.39
Formula:
C₁₈H₁₉N₇O
SMILES:
CCN(CC1=NC2=C(N)N=C3C=C(C=CC3=C2[NH]1)C4=N[NH]C=C4)C(C)=O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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