Borussertib
Selleck Chemicals
SKU:S8839-2MG
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Borussertib is an inhibitor of AKT and PKA used in studies of PI3K-Akt-mTOR Signaling. It is especially relevant in cancer, cell signaling, and metabolism models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs.
By inhibiting AKT and PKA, Borussertib can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving AKT and PKA
- Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling
- Concentration-response inhibition and target-dependence studies
- Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
Overall, Borussertib is appropriate when a defined chemical perturbant is needed to connect AKT and PKA with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- AKT • PKA
- Target Class:
- Kinase
- Pathways:
- PI3K-Akt-mTOR Signaling
- Research Area:
- Cancer • Cell Signaling • Metabolism
- CAS No.:
- 1800070-77-2
- Molecular Weight:
- 596.68
- Formula:
- C₃₆H₃₂N₆O₃
- SMILES:
- C=CC(=O)NC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)CC4=CC=C(C=C4)C5=C(C=C6C(=N5)C=CNC6=O)C7=CC=CC=C7
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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