BRE Antibody

About the Target

BRE (Brain and reproductive organ-expressed protein), also known as BRCC45, is a multifunctional protein found in both the cytoplasm and nucleus, encoded by a stress-responsive gene producing multiple mRNA isoforms. Structurally, BRE is a component of the BRCA1-A complex, where it interacts with proteins like MERIT40 to facilitate DNA damage repair through homologous recombination. Depending on the literature source, BRE may also be discussed as BRISC and BRCA1-A complex member 2 and BRCA1-A complex subunit BRE.

Reported cellular context includes cytoplasm and nucleus, which can matter when signal is compared across treatments or changing cell states. Following BRE across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

BRE is commonly interpreted in the context of cancer, dna damage / repair, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between cytoplasm and nucleus across matched conditions
• changes associated with proliferative state, oncogenic signaling, or treatment response
• stress-induced changes after checkpoint activation or genotoxic challenge
• signal-dependent shifts after ligand, inhibitor, or growth-factor perturbation

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for BRE. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in BRE reflect biology rather than handling. When interpreting BRE, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep BRE trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.