Cabozantinib (XL184)

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Selleck Chemicals

S1119-5MG

€144,00 EUR
€144,00 EUR
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Cabozantinib (XL184) is an inhibitor of VEGFR2 and c-Met used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in angiogenesis, apoptosis, and cancer models.

By inhibiting VEGFR2 and c-Met, Cabozantinib (XL184) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving VEGFR2 and c-Met
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Cabozantinib (XL184) is appropriate when a defined chemical perturbant is needed to connect VEGFR2 and c-Met with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
VEGFR2 • c-Met
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • NF-kB Signaling
Research Area:
Angiogenesis • Apoptosis • Cancer • Cell Signaling
CAS No.:
849217-68-1
Molecular Weight:
501.51
Formula:
C₂₈HFN₃O₅
SMILES:
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
InChIKey:
ONIQOQHATWINJY-UHFFFAOYSA-N
PubChem:
25102847
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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