Calcium folinate (Leucovorin calcium)

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Selleck Chemicals

S5136-25MG

€95,00 EUR
€95,00 EUR
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Calcium folinate (Leucovorin calcium) is an inhibitor of DHFR used in studies of DNA Damage Response. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control in cancer, dna damage / repair, and metabolism models.

By inhibiting DHFR, Calcium folinate (Leucovorin calcium) can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, dna damage / repair, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving DHFR
  • Pathway perturbation studies connected to DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, Calcium folinate (Leucovorin calcium) is appropriate when a defined chemical perturbant is needed to connect DHFR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, dna damage / repair, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
DHFR
Target Class:
Enzyme
Pathways:
DNA Damage Response
Research Area:
Cancer • DNA Damage / Repair • Metabolism
CAS No.:
1492-18-8
Molecular Weight:
511.5
Formula:
C₂₀H₂₁N₇O₇·Ca
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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