Caspase-4 (CASP4) Antibody
BiCell Scientific
SKU:10304-50UL
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Scientific Overview
This antibody supports efforts to explore Caspase-4 and interpret it within interaction networks. Caspase-4 is a molecular target often examined to connect phenotype changes with underlying protein regulation. Many projects interpret this target alongside interacting partners, upstream cues, and downstream readouts.
In some datasets and protocols, it is referenced by the gene symbol CASP4.
Research Relevance
Comparative experiments across cell states can uncover patterns that single-condition measurements miss. Considering complex membership and compartment shifts can clarify whether changes reflect signaling or redistribution.
When cell-state transitions occur, this target may change alongside partners in the same compartment or pathway neighborhood.
When building a narrative around the target, it helps to track:
- cross-sample normalization strategies
- interpretation alongside orthogonal readouts
- baseline versus stimulated condition comparisons
Application-Specific Context
When assay conditions are still being tuned, a regular-format antibody supports stepwise adjustment of buffers and incubation steps. Think about how preparation affects epitope accessibility, and interpret patterns alongside morphology and compartment markers as needed. If signaling is transient, sampling time can be as important as condition.
If your study spans multiple model systems, it can help to define a shared reference condition for Caspase-4 so cross-sample contrasts stay meaningful.
When interpreting Caspase-4, consider whether changes track with compartment identity, cell density, or perturbation timing; these factors can influence apparent signal without implying a direct causal link.
Use the regular format version to relate Caspase-4 behavior to upstream cues and downstream consequences.
- Targets:
- CASP4
- Research Area:
- Apoptosis • Inflammation
- Application:
- IF • IHC • WB
- Reactivity:
- Human • Mouse • Rat
- Host:
- Rat
- Clonality:
- Polyclonal
- Isotype:
- IgG
- Immunogen:
- Synthetic peptide (16-aa) derived from the C-terminal region of mouse Caspase-4 protein (p10 subunit)
- Conjugation:
- Unconjugated
- Purification:
- Affinity Chromatography
- Concentration:
- 0.25 mg/ml
- UniProt:
- P49662
- Homology:
- Synthetic peptide sequence is identical to rat sequence (showing 75% homology to human sequence)
- Storage Buffer:
- PBS, pH 7.2, 0.1% Sodium Azide
- Storage Temperature:
- -20°C