CaSR Antibody - FFPE Validated
BiCell Scientific
SKU:50102-FFPE-50UL
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Scientific Overview
For consistent comparison across experiments, use this antibody to assess CaSR with a repeatable workflow. CaSR is a signaling node often evaluated by abundance, localization, and modification-dependent states. Use matched handling so differences reflect biology rather than processing.
Tracking CaSR can clarify whether changes reflect regulation, redistribution, or altered complex assembly.
Research Relevance
Perturbations such as inhibitors or ligand stimulation can drive rapid shifts in localization or complex formation. Define inclusion criteria and controls early so replicate sets remain interpretable as the dataset grows.
Since many cellular processes are coupled, measured differences can reflect both direct regulation and indirect effects from broader state changes.
When building a narrative around the target, it helps to track:
- time-resolved changes following stimulation or inhibition
- condition-to-condition comparisons with matched controls
- interaction patterns within multi-protein complexes
- localization shifts between cytoplasm, membrane, and nucleus
Application-Specific Context
In sectioned tissue workflows, interpretation often depends on morphology; this format supports that style of readout. Think about how preparation affects epitope accessibility, and interpret patterns alongside morphology and compartment markers as needed. A short pilot series can help set exposure ranges and reduce reruns.
When interpreting CaSR, consider whether changes track with compartment identity, cell density, or perturbation timing; these factors can influence apparent signal without implying a direct causal link.
Pair this fixed-section format with stable controls to keep CaSR measurements coherent over time.
- Targets:
- CASR
- Research Area:
- Cardiovascular • Cell Signaling • Endocrinology • Metabolism
- Application:
- IHC-P
- Reactivity:
- Human • Mouse • Rat
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Isotype:
- IgG
- Immunogen:
- Synthetic peptide (17-aa) derived from the C-terminal cytoplasmic region of mouse CaSR protein
- Conjugation:
- Unconjugated
- Purification:
- Affinity Chromatography
- Concentration:
- 0.25 mg/ml
- UniProt:
- P41180
- Homology:
- Synthetic peptide sequence is identical to rat sequence (showing 82.4% homology to human sequence)
- Storage Buffer:
- PBS, pH 7.2, 0.1% Sodium Azide
- Storage Temperature:
- -20°C