CCT128930

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Selleck Chemicals

S2635-5MG

€167,00 EUR
€167,00 EUR
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CCT128930 is an inhibitor of PKA and S6K and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in apoptosis, autophagy, and cancer models.

By inhibiting PKA and S6K and related targets, CCT128930 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PKA and S6K and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, CCT128930 is appropriate when a defined chemical perturbant is needed to connect PKA and S6K and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PKA • S6K • AKT2
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • DNA Damage Response • Apoptosis
Research Area:
Apoptosis • Autophagy • Cancer • Cell Cycle
CAS No.:
885499-61-6
Molecular Weight:
341.84
Formula:
C₁₈H₂₀ClN₅
SMILES:
C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.