Thrombomodulin Antibody

About the Target

CD141 is a target of interest in many antibody-based workflows. Thrombomodulin (TM) is a high-affinity receptor for thrombin located on the membrane of endothelial cells, playing a crucial role as a natural anticoagulant. By acting as a cofactor in the thrombin-catalyzed activation of protein C, TM inhibits the procoagulant functions of thrombin, thereby contributing to the regulation of blood coagulation and maintaining vascular homeostasis. Depending on the literature source, CD141 may also be discussed as Thrombomodulin and TM.

Reported cellular context includes membrane, which can matter when signal is compared across treatments or changing cell states. Following CD141 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

CD141 is commonly interpreted in the context of immunology and cardiovascular research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• signal enrichment within membrane relative to the broader cellular background
• context differences tied to immune-cell state, activation, or lineage composition
• changes linked to vascular, contractile, or hemodynamic cell-state cues
• co-patterning with orthogonal markers and control conditions that clarify pathway state

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CD141. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CD141 reflect biology rather than handling. When interpreting CD141, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep CD141 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.