CD163 Antibody

About the Target

CD163 is a transmembrane scavenger receptor found on the surface of macrophages. It features nine B-type Scavenger Receptor Cysteine-Rich (SRCR) extracellular domains that facilitate the clearance and endocytosis of serum haptoglobin, pathogen binding, signal transduction, and calcium binding. CD163 serves as a marker for M2 type macrophages, including M2 type tumor-associated macrophages (TAMs), which contribute to cancer progression by secreting cytokines that promote angiogenesis, immunosuppression, and metastasis.

Reported cellular context includes secreted and cell membrane, which can matter when signal is compared across treatments or changing cell states. Following CD163 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

CD163 is commonly interpreted in the context of cancer, immunology, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans secreted and cell membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between secreted and cell membrane across matched conditions
• changes associated with proliferative state, oncogenic signaling, or treatment response
• context differences tied to immune-cell state, activation, or lineage composition
• signal-dependent shifts after ligand, inhibitor, or growth-factor perturbation

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CD163. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CD163 reflect biology rather than handling. When interpreting CD163, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep CD163 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.