CD31 (PECAM-1) Antibody

About the Target

Platelet/endothelial cell adhesion molecule-1 (PECAM-1), also known as CD31, is a vital cell adhesion and signaling molecule predominantly found in endothelial cells, circulating platelets, monocytes, neutrophils, and some T cells. It plays a crucial role in maintaining vascular integrity by facilitating homophilic interactions that concentrate PECAM-1 at endothelial junctions, thereby supporting vascular permeability and leukocyte migration. Depending on the literature source, CD31 may also be discussed as CD31 (PECAM-1) and PECAM-1.

Reported cellular context includes cell junction, cell membrane, and membrane, which can matter when signal is compared across treatments or changing cell states. Following CD31 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

CD31 is commonly interpreted in the context of immunology, cardiovascular, and angiogenesis research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell junction, cell membrane, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between cell junction, cell membrane, and membrane across matched conditions
• context differences tied to immune-cell state, activation, or lineage composition
• changes linked to vascular, contractile, or hemodynamic cell-state cues
• differences related to endothelial activation, vessel remodeling, or growth-factor exposure

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CD31. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CD31 reflect biology rather than handling. When interpreting CD31, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep CD31 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.