CD36 Antibody

About the Target

CD36 is a heavily glycosylated integral membrane protein and scavenger receptor widely expressed in various tissues, including adipocytes, myocytes, enterocytes, immune cells, and endothelial cells. Structurally, it features two transmembrane domains, two short intracellular domains at both termini (short cytoplasmic tails), and a large extracellular domain containing a conserved hydrophobic pocket and multiple ligand-binding sites. Depending on the literature source, CD36 may also be discussed as GP3B and GP4.

Reported cellular context includes cell membrane, golgi apparatus, and membrane, which can matter when signal is compared across treatments or changing cell states. Following CD36 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

CD36 is commonly interpreted in the context of immunology, metabolism, and infectious disease research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, golgi apparatus, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between cell membrane, golgi apparatus, and membrane across matched conditions
• context differences tied to immune-cell state, activation, or lineage composition
• responses linked to nutrient status, mitochondrial state, or metabolic rewiring
• host-response changes during infection or pathogen-associated stimulation

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CD36. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CD36 reflect biology rather than handling. When interpreting CD36, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep CD36 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.