CD55 Antibody

About the Target

CD55, also known as decay-accelerating factor (DAF), is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein primarily known for its role in regulating the complement system by accelerating the decay of C3 and C5 convertases, thereby protecting cells from complement-mediated damage. Structurally, CD55 comprises four short consensus repeat (SCR) domains, a serine/threonine/proline-rich O-linked glycosylation domain, and a GPI anchor that localizes it to lipid rafts on the plasma membrane. Depending on the literature source, CD55 may also be discussed as CR and DAF.

Reported cellular context includes cell membrane, membrane, and secreted, which can matter when signal is compared across treatments or changing cell states. Following CD55 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

CD55 is commonly interpreted in the context of cancer, immunology, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, membrane, and secreted, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between cell membrane, membrane, and secreted across matched conditions
• changes associated with proliferative state, oncogenic signaling, or treatment response
• context differences tied to immune-cell state, activation, or lineage composition
• signal-dependent shifts after ligand, inhibitor, or growth-factor perturbation

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CD55. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CD55 reflect biology rather than handling. When interpreting CD55, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep CD55 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.