Connexin-45 (Cx45 or Gjc1) Antibody

Scientific Overview

Bring Connexin-45 into view to examine changes across conditions. Connexin-45 is a junctional protein that coordinates adhesion with cytoskeletal anchoring. Look for shifts in distribution that track with phenotype changes.

In some datasets and protocols, it is referenced by the gene symbol Cx45.

Research Relevance

In cultured models, junctional readouts can change rapidly after calcium modulation or cytoskeletal perturbation. Pair measurements with orthogonal readouts when interpretation is sensitive to context.

When cell-state transitions occur, this target may change alongside partners in the same compartment or pathway neighborhood.

When building a narrative around the target, it helps to track:

• subcellular redistribution at contact sites versus cytoplasm
• co-localization patterns with cytoskeletal elements
• comparative profiling across cell states or perturbations
• changes in complex assembly with scaffold or adaptor proteins

Application-Specific Context

This regular format is a practical starting point when you want flexibility across sample types and iterative optimization. Think about how preparation affects epitope accessibility, and interpret patterns alongside morphology and compartment markers as needed.

For challenging targets, pairing Connexin-45 measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

For challenging targets, pairing Connexin-45 measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

With a clear focus on Connexin-45, this regular format option fits streamlined studies and fast iteration.