CYC116

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Selleck Chemicals

S1171-10MG

€144,00 EUR
€144,00 EUR
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CYC116 is an inhibitor of Aurora Kinases and VEGFR2 used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in angiogenesis, cancer, and cell cycle models.

By inhibiting Aurora Kinases and VEGFR2, CYC116 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Aurora Kinases and VEGFR2
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, CYC116 is appropriate when a defined chemical perturbant is needed to connect Aurora Kinases and VEGFR2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Aurora Kinases • VEGFR2
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • Cell Cycle Regulation
Research Area:
Angiogenesis • Cancer • Cell Cycle • Cell Signaling
CAS No.:
693228-63-6
Molecular Weight:
368.46
Formula:
C₁₈H₂₀N₆OS
SMILES:
CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4
InChIKey:
GPSZYOIFQZPWEJ-UHFFFAOYSA-N
PubChem:
6420138
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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