CZC-25146
Selleck Chemicals
SKU:S2002-5MG
Couldn't load pickup availability
CZC-25146 is an inhibitor of LRRK2 used in studies of Autophagy. It is especially relevant in autophagy, cancer, and cell signaling models, where defined compound exposure can be linked to autophagic flux, lysosomal turnover, and stress adaptation.
By inhibiting LRRK2, CZC-25146 can be used to examine autophagic flux, lysosomal turnover, and stress adaptation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving LRRK2
- Pathway perturbation studies connected to Autophagy
- Concentration-response inhibition and target-dependence studies
- Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
Overall, CZC-25146 is appropriate when a defined chemical perturbant is needed to connect LRRK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- LRRK2
- Target Class:
- Kinase
- Pathways:
- Autophagy
- Research Area:
- Autophagy • Cancer • Cell Signaling • Neuroscience
- CAS No.:
- 1191911-26-8
- Molecular Weight:
- 488.54
- Formula:
- C₂₂H₂₅FN₆O₄S
- SMILES:
- COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
Products may be subject to intellectual property rights.
The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.