D 4476

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Selleck Chemicals

S7642-10MG

€144,00 EUR
€144,00 EUR
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D 4476 is an inhibitor of CK2 used in studies of kinase signaling. In practice, this places the compound in experiments that measure phosphorylation signaling, target engagement, and selectivity relationships in cancer, cell signaling, and metabolism models.

By inhibiting CK2, D 4476 can be used to examine phosphorylation signaling, target engagement, and selectivity relationships. This target class is commonly examined through biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping. In cancer, cell signaling, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving CK2
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
  • Phenotypic profiling in cancer, cell signaling, and metabolism models

Overall, D 4476 is appropriate when a defined chemical perturbant is needed to connect CK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
CK2
Target Class:
Kinase
Research Area:
Cancer • Cell Signaling • Metabolism
CAS No.:
301836-43-1
Molecular Weight:
398.41
Formula:
C₂₃H₁₈N₄O₃
SMILES:
C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.