Daprodustat (GSK1278863)

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Selleck Chemicals

S8171-5MG

€144,00 EUR
€144,00 EUR
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Daprodustat (GSK1278863) is a modulator of HIF used in studies of pathway modulation. In practice, this places the compound in experiments that measure pathway-dependent signal amplification or attenuation in angiogenesis, cancer, and cell signaling models.

By modulating HIF, Daprodustat (GSK1278863) can be used to examine pathway-dependent signal amplification or attenuation. This target class is commonly examined through pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HIF
  • Context-dependent response profiling and mechanism comparison
  • Pathway-reporter and mechanistic-phenotyping studies
  • Phenotypic profiling in angiogenesis, cancer, and cell signaling models

Overall, Daprodustat (GSK1278863) is appropriate when a defined chemical perturbant is needed to connect HIF with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HIF
Target Class:
Signaling Pathway Modulator
Research Area:
Angiogenesis • Cancer • Cell Signaling
CAS No.:
960539-70-2
Molecular Weight:
393.43
Formula:
C₁₉H₂₇N₃O₆
SMILES:
C1CCC(CC1)N2C(=O)C(C(=O)N(C2=O)C3CCCCC3)C(=O)NCC(=O)O
InChIKey:
RUEYEZADQJCKGV-UHFFFAOYSA-N
PubChem:
91617630
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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