Elacridar (GF120918)

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Selleck Chemicals

S7772-10MG

€144,00 EUR
€144,00 EUR
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Elacridar (GF120918) is an inhibitor of P-gp used in studies of transporter biology. In practice, this places the compound in experiments that measure substrate uptake, efflux, and membrane-transport control in cancer and infectious disease models.

By inhibiting P-gp, Elacridar (GF120918) can be used to examine substrate uptake, efflux, and membrane-transport control. This target class is commonly examined through transport, uptake/efflux, and permeability assays, together with downstream-response mapping. In cancer and infectious disease models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving P-gp
  • Concentration-response inhibition and target-dependence studies
  • Transport, uptake/efflux, and permeability assays
  • Phenotypic profiling in cancer and infectious disease models

Overall, Elacridar (GF120918) is appropriate when a defined chemical perturbant is needed to connect P-gp with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and infectious disease models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
P-gp
Target Class:
Transporter
Research Area:
Cancer • Infectious Disease
CAS No.:
143664-11-3
Molecular Weight:
563.64
Formula:
C₃₄H₃₃N₃O₅
SMILES:
COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
InChIKey:
OSFCMRGOZNQUSW-UHFFFAOYSA-N
PubChem:
119373
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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