ErbB2 (HER2 or Neu or CD340) Antibody - Western Blot Validated
BiCell Scientific
SKU:52002-WB-50UL
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About the Target
This antibody enables you to analyze ErbB2 (HER2) with a direct, biology-first readout. ErbB2 is a pathway component whose activation state and localization can change after stimulation. Look for shifts in distribution that track with phenotype changes.
Tracking ErbB2 can clarify whether changes reflect regulation, redistribution, or altered complex assembly.
Research Context
Perturbations such as inhibitors or ligand stimulation can drive rapid shifts in localization or complex formation. Pair measurements with orthogonal readouts when interpretation is sensitive to context. In oncology research models, expression shifts can accompany changes in adhesion, signaling, or differentiation state.
Consider these angles when interpreting target-level changes:
- interaction patterns within multi-protein complexes
- condition-to-condition comparisons with matched controls
- localization shifts between cytoplasm, membrane, and nucleus
- time-resolved changes following stimulation or inhibition
Variant Considerations
When samples are prepared in reducing conditions, some epitopes become more accessible; this version is designed with that context in mind. This matters because epitope exposure and background can vary with preparation and extraction steps. If you compare conditions, keep processing steps uniform to support clean interpretation.
For challenging targets, pairing ErbB2 measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.
For challenging targets, pairing ErbB2 measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.
Select the denaturing-format version to keep ErbB2 (HER2) interpretation aligned with your workflow goals.
- Targets:
- ERBB2
- Research Area:
- Cancer • Cell Signaling
- Application:
- WB
- Reactivity:
- Human • Mouse • Rat
- Host:
- Rat
- Clonality:
- Polyclonal
- Isotype:
- IgG
- Immunogen:
- Synthetic peptide (14-aa) derived from the C-terminal region of human ErbB2 protein
- Conjugation:
- Unconjugated
- Purification:
- Affinity Chromatography
- Concentration:
- 0.25 mg/ml
- UniProt:
- P04626
- Homology:
- Synthetic peptide sequence is identical to rat or mouse sequence
- Storage Buffer:
- PBS, pH 7.2, 0.1% Sodium Azide
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.