Fasudil (HA-1077)Hydrochloride

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Selleck Chemicals

S1573-200MG

€144,00 EUR
€144,00 EUR
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Fasudil (HA-1077)Hydrochloride is an inhibitor of ROCK and PKA and related targets used in studies of MAPK / ERK Signaling and Calcium Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and calcium flux, excitability, and secretion-linked signaling in cancer, cardiovascular, and cell cycle models.

By inhibiting ROCK and PKA and related targets, Fasudil (HA-1077)Hydrochloride can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and calcium flux, excitability, and secretion-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cardiovascular, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving ROCK and PKA and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and Calcium Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Fasudil (HA-1077)Hydrochloride is appropriate when a defined chemical perturbant is needed to connect ROCK and PKA and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
ROCK • PKA • PKC • Calcium Channels
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • Calcium Signaling
Research Area:
Cancer • Cardiovascular • Cell Cycle • Cell Signaling
CAS No.:
105628-07-7
Molecular Weight:
327.83
Formula:
C₁₄H₁₇N₃O₂S·HCl
SMILES:
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.