GDC046

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Selleck Chemicals

S0374-5MG

€458,00 EUR
€458,00 EUR
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GDC046 is an inhibitor of JAK1 and JAK2 and related targets used in studies of JAK-STAT Signaling. It is especially relevant in cancer, cell signaling, and immunology models, where defined compound exposure can be linked to cytokine-responsive transcriptional signaling and immune regulation.

By inhibiting JAK1 and JAK2 and related targets, GDC046 can be used to examine cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving JAK1 and JAK2 and related targets
  • Pathway perturbation studies connected to JAK-STAT Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, GDC046 is appropriate when a defined chemical perturbant is needed to connect JAK1 and JAK2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
JAK1 • JAK2 • JAK3 • TYK2
Target Class:
Kinase
Pathways:
JAK-STAT Signaling
Research Area:
Cancer • Cell Signaling • Immunology • Inflammation
CAS No.:
1258292-64-6
Molecular Weight:
350.20
Formula:
C₁₆H₁₃Cl₂N₃O₂
SMILES:
C1CC1C(=O)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.