GSK481

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Selleck Chemicals

S8169-2MG

€95,00 EUR
€95,00 EUR
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GSK481 is an inhibitor of RIPK used in studies of Apoptosis. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions in apoptosis, cancer, and cell signaling models.

By inhibiting RIPK, GSK481 can be used to examine caspase-associated cell-death signaling and survival decisions. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving RIPK
  • Pathway perturbation studies connected to Apoptosis
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, GSK481 is appropriate when a defined chemical perturbant is needed to connect RIPK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
RIPK
Target Class:
Kinase
Pathways:
Apoptosis
Research Area:
Apoptosis • Cancer • Cell Signaling • Immunology
CAS No.:
1622849-58-4
Molecular Weight:
377.39
Formula:
C₂₁H₁₉N₃O₄
SMILES:
CN1C2=CC=CC=C2OCC(C1=O)NC(=O)C3=NOC(=C3)CC4=CC=CC=C4
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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