(-)-Huperzine A (HupA)

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Selleck Chemicals

S2251-2MG

€144,00 EUR
€144,00 EUR
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(-)-Huperzine A (HupA) is an inhibitor of AChR and NMDAR used in studies of Calcium Signaling and Neurotransmission. In practice, this places the compound in experiments that measure calcium flux, excitability, and secretion-linked signaling and synaptic signaling, receptor activity, and neuronal excitability in neuroscience models.

By inhibiting AChR and NMDAR, (-)-Huperzine A (HupA) can be used to examine calcium flux, excitability, and secretion-linked signaling and synaptic signaling, receptor activity, and neuronal excitability. This context is compatible with calcium-mobilization, membrane-activity, and signaling assays and electrophysiology, neurotransmission, and receptor-response assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In neuroscience models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving AChR and NMDAR
  • Pathway perturbation studies connected to Calcium Signaling and Neurotransmission
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in neuroscience models

Overall, (-)-Huperzine A (HupA) is appropriate when a defined chemical perturbant is needed to connect AChR and NMDAR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in neuroscience models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
AChR • NMDAR
Target Class:
Other
Pathways:
Calcium Signaling • Neurotransmission
Research Area:
Neuroscience
CAS No.:
102518-79-6
Molecular Weight:
24232
Formula:
C₁₅H₁₈N₂O
SMILES:
CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3
InChIKey:
ZRJBHWIHUMBLCN-QDEBKDIKSA-N
PubChem:
854026
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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