Hydroxyfasudil HCl

1 1

Selleck Chemicals

S8208-5MG

€144,00 EUR
€144,00 EUR
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Hydroxyfasudil HCl is an inhibitor of PKA and ROCK1 and related targets used in studies of kinase signaling. It is especially relevant in cancer, cardiovascular, and cell cycle models, where defined compound exposure can be linked to phosphorylation signaling, target engagement, and selectivity relationships.

By inhibiting PKA and ROCK1 and related targets, Hydroxyfasudil HCl can be used to examine phosphorylation signaling, target engagement, and selectivity relationships. This target class is commonly examined through biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping. In cancer, cardiovascular, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PKA and ROCK1 and related targets
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
  • Phenotypic profiling in cancer, cardiovascular, and cell cycle models

Overall, Hydroxyfasudil HCl is appropriate when a defined chemical perturbant is needed to connect PKA and ROCK1 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PKA • ROCK1 • ROCK2
Target Class:
Kinase
Research Area:
Cancer • Cardiovascular • Cell Cycle • Cell Signaling
CAS No.:
155558-32-0
Molecular Weight:
343.83
Formula:
C₁₄H₁₇N₃O₃S·HCl·xH₂O
SMILES:
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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