Iberdomide (CC-220)

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Selleck Chemicals

S8760-2MG

€144,00 EUR
€144,00 EUR
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Iberdomide (CC-220) is a modulator of E3 Ligase used in studies of Apoptosis and Protein Degradation / Proteasome. It is especially relevant in apoptosis, cancer, and immunology models, where defined compound exposure can be linked to caspase-associated cell-death signaling and survival decisions and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation.

By modulating E3 Ligase, Iberdomide (CC-220) can be used to examine caspase-associated cell-death signaling and survival decisions and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving E3 Ligase
  • Pathway perturbation studies connected to Apoptosis and Protein Degradation / Proteasome
  • Context-dependent response profiling and mechanism comparison
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, Iberdomide (CC-220) is appropriate when a defined chemical perturbant is needed to connect E3 Ligase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
E3 Ligase
Target Class:
Enzyme
Pathways:
Apoptosis • Protein Degradation / Proteasome
Research Area:
Apoptosis • Cancer • Immunology • Inflammation
CAS No.:
1323403-33-3
Molecular Weight:
449.50
Formula:
C₂₅H₂₇N₃O₅
SMILES:
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5
InChIKey:
IXZOHGPZAQLIBH-UHFFFAOYSA-N
PubChem:
67335295
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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