Ibrutinib (PCI-32765)

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Selleck Chemicals

S2680-5MG

€167,00 EUR
€167,00 EUR
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Ibrutinib (PCI-32765) is an inhibitor of BTK and RET and related targets used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in angiogenesis, cancer, and cell signaling models.

By inhibiting BTK and RET and related targets, Ibrutinib (PCI-32765) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving BTK and RET and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Ibrutinib (PCI-32765) is appropriate when a defined chemical perturbant is needed to connect BTK and RET and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
BTK • RET • EGFR • HER2
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • Immune Signaling
Research Area:
Angiogenesis • Cancer • Cell Signaling • Immunology
CAS No.:
936563-96-1
Molecular Weight:
440.5
Formula:
C₂₅H₂₄N₆O₂
SMILES:
C=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N
InChIKey:
XYFPWWZEPKGCCK-UHFFFAOYSA-N
PubChem:
24821094
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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