ICG-001

1 1

Selleck Chemicals

S2662-5MG

€144,00 EUR
€144,00 EUR
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ICG-001 is an inhibitor of Wnt / beta-catenin used in studies of Wnt Signaling and Apoptosis. In practice, this places the compound in experiments that measure beta-catenin-dependent transcription and developmental signaling and caspase-associated cell-death signaling and survival decisions in apoptosis, cancer, and cell signaling models.

By inhibiting Wnt / beta-catenin, ICG-001 can be used to examine beta-catenin-dependent transcription and developmental signaling and caspase-associated cell-death signaling and survival decisions. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Wnt / beta-catenin
  • Pathway perturbation studies connected to Wnt Signaling and Apoptosis
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, ICG-001 is appropriate when a defined chemical perturbant is needed to connect Wnt / beta-catenin with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Wnt / beta-catenin
Target Class:
Signaling Pathway Modulator
Pathways:
Wnt Signaling • Apoptosis
Research Area:
Apoptosis • Cancer • Cell Signaling • Developmental Biology
CAS No.:
780757-88-2 (relative stereochemistry), 847591-62-2 (absolute stereochemistry)
Molecular Weight:
548.63
Formula:
C₃₃H₃₂N₄O₄
SMILES:
C1CN(C2CN(C(=O)C(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.