Imatinib (STI571)Mesylate

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Selleck Chemicals

S1026-100MG

€144,00 EUR
€144,00 EUR
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Imatinib (STI571)Mesylate is an inhibitor of PDGFR and c-Kit used in studies of MAPK / ERK Signaling and Autophagy. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and autophagic flux, lysosomal turnover, and stress adaptation in angiogenesis, autophagy, and cancer models.

By inhibiting PDGFR and c-Kit, Imatinib (STI571)Mesylate can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and autophagic flux, lysosomal turnover, and stress adaptation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PDGFR and c-Kit
  • Pathway perturbation studies connected to MAPK / ERK Signaling and Autophagy
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Imatinib (STI571)Mesylate is appropriate when a defined chemical perturbant is needed to connect PDGFR and c-Kit with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PDGFR • c-Kit
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • Autophagy
Research Area:
Angiogenesis • Autophagy • Cancer • Cell Signaling
CAS No.:
220127-57-1
Molecular Weight:
589.71
Formula:
C₂₉H₃₁N₇O·CH₄SO₃
SMILES:
CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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