Integrin alpha-M (ITGAM or CD11b) Antibody

Biological Background

This antibody is suited for researchers who want to investigate Integrin alpha-M and relate it to cell-state biology. Integrin alpha-M is an extracellular or receptor-linked component that coordinates matrix engagement with cytoskeletal remodeling. Its behavior can reflect changes in differentiation state, stress, or remodeling of cellular architecture.

In some datasets and protocols, it is referenced by the gene symbol ITGAM.

Use in the Laboratory

Perturbations that disrupt integrin engagement or actomyosin tension can reshape localization and complex assembly. Because regulation can be multi-layered, combining abundance and localization information can sharpen conclusions.

Many targets show context-dependent localization, so comparisons across matched conditions can reveal meaningful patterns.

To keep datasets interpretable, labs often document:

• co-variation with cytoskeletal and scaffold partners
• focal adhesion versus diffuse membrane distribution
• effects of adhesion inhibitors or matrix composition

Version Notes

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior. If your study compares multiple conditions, keep acquisition and processing settings stable to avoid confounding. Small differences in preparation can reshape apparent localization, so interpret results in context.

If your study spans multiple model systems, it can help to define a shared reference condition for Integrin alpha-M so cross-sample contrasts stay meaningful.

As you refine hypotheses around Integrin alpha-M, the regular format format helps keep conclusions tied to preparation context.