Integrin alpha-M (ITGAM or CD11b) Antibody - FFPE Validated

About the Target

This antibody supports efforts to evaluate Integrin alpha-M (ITGAM) and interpret it within interaction networks. Integrin alpha-M is an extracellular or receptor-linked component that coordinates matrix engagement with cytoskeletal remodeling. Many projects interpret this target alongside interacting partners, upstream cues, and downstream readouts.

In some datasets and protocols, it is referenced by the gene symbol ITGAM.

Research Context

Because adhesion complexes are dynamic, timing and confluence can strongly influence measured signal. Considering complex membership and compartment shifts can clarify whether changes reflect signaling or redistribution.

Consider these angles when interpreting target-level changes:

• co-variation with cytoskeletal and scaffold partners
• effects of adhesion inhibitors or matrix composition
• focal adhesion versus diffuse membrane distribution

Variant Considerations

This fixed-section oriented version is intended for paraffin-embedded tissue, where crosslinking and retrieval steps can shape epitope accessibility. This matters because epitope exposure and background can vary with preparation and extraction steps. If you compare conditions, keep processing steps uniform to support clean interpretation.

When interpreting Integrin alpha-M, consider whether changes track with compartment identity, cell density, or perturbation timing; these factors can influence apparent signal without implying a direct causal link.

For challenging targets, pairing Integrin alpha-M measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

The fixed-section option supports mechanistic reading of Integrin alpha-M (ITGAM) when interactions and context are the focus.