Integrin alpha-V (ITGAV or CD51) Antibody - FFPE Validated

Biological Background

Designed to help you analyze Integrin alpha-V (CD51), this antibody supports studies where protein context matters. Integrin alpha-V is a matrix-interaction protein often examined in migration and morphogenesis models. Its behavior can reflect changes in differentiation state, stress, or remodeling of cellular architecture.

In some datasets and protocols, it is referenced by the gene symbol CD51.

Use in the Laboratory

Because adhesion complexes are dynamic, timing and confluence can strongly influence measured signal. Because regulation can be multi-layered, combining abundance and localization information can sharpen conclusions.

Depending on the model, researchers may ask whether signal shifts reflect altered abundance, compartment changes, or remodeling of associated complexes.

To keep datasets interpretable, labs often document:

• focal adhesion versus diffuse membrane distribution
• remodeling after changes in substrate or mechanical stress
• effects of adhesion inhibitors or matrix composition

Version Notes

Because fixation can mask epitopes, fixed-section oriented formats aim to maintain recognition after standard deparaffinization and retrieval steps. If your study compares multiple conditions, keep acquisition and processing settings stable to avoid confounding. Small differences in preparation can reshape apparent localization, so interpret results in context.

To support downstream analysis, record key context variables (culture timing, stimulation window, and extraction approach) so Integrin alpha-V patterns can be compared across experiments without guesswork.

The fixed-section version supports deeper biological narratives around Integrin alpha-V (CD51) without overcomplicating setup.