IPI-145 (Duvelisib)

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Selleck Chemicals

S7028-5MG

€167,00 EUR
€167,00 EUR
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IPI-145 (Duvelisib) is an inhibitor of PI3K beta and PI3K delta and related targets used in studies of PI3K-Akt-mTOR Signaling. It is especially relevant in angiogenesis, cancer, and cell signaling models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs.

By inhibiting PI3K beta and PI3K delta and related targets, IPI-145 (Duvelisib) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PI3K beta and PI3K delta and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, IPI-145 (Duvelisib) is appropriate when a defined chemical perturbant is needed to connect PI3K beta and PI3K delta and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PI3K beta • PI3K delta • PI3K gamma
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling
Research Area:
Angiogenesis • Cancer • Cell Signaling • Immunology
CAS No.:
1201438-56-3
Molecular Weight:
416.86
Formula:
C₂₂H₁₇ClN₆O
SMILES:
CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
InChIKey:
SJVQHLPISAIATJ-UHFFFAOYSA-N
PubChem:
50905713
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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