IRAK4-IN-2

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Selleck Chemicals

S8562-2MG

€114,00 EUR
€114,00 EUR
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IRAK4-IN-2 is an inhibitor of TLR used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling in immunology and inflammation models.

By inhibiting TLR, IRAK4-IN-2 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TLR
  • Pathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, IRAK4-IN-2 is appropriate when a defined chemical perturbant is needed to connect TLR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TLR
Target Class:
Immunomodulator
Pathways:
JAK-STAT Signaling • NF-kB Signaling • Immune Signaling
Research Area:
Immunology • Inflammation
CAS No.:
1801343-74-7
Molecular Weight:
417.42
Formula:
C₂₁H₁₉N₇O₃
SMILES:
C1COCCN1C2=NC3=C(O2)C=C(C=N3)NC(=O)C4=CC=CC(=N4)C5=CN=C(C=C5)N
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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