Itacitinib (INCB39110)

1 1

Selleck Chemicals

S7812-2MG

€144,00 EUR
€144,00 EUR
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Itacitinib (INCB39110) is an inhibitor of JAK1 used in studies of JAK-STAT Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to cytokine-responsive transcriptional signaling and immune regulation in cancer, cell signaling, and immunology models.

By inhibiting JAK1, Itacitinib (INCB39110) can be used to examine cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving JAK1
  • Pathway perturbation studies connected to JAK-STAT Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Itacitinib (INCB39110) is appropriate when a defined chemical perturbant is needed to connect JAK1 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
JAK1
Target Class:
Kinase
Pathways:
JAK-STAT Signaling
Research Area:
Cancer • Cell Signaling • Immunology • Inflammation
CAS No.:
1334298-90-6
Molecular Weight:
553.51
Formula:
C₂₆H₂₃F₄N₉O
SMILES:
C1CN(CCC1N2CC(C2)(CC#N)N3C=C(C=N3)C4=C5C=CNC5=NC=N4)C(=O)C6=C(C(=NC=C6)C(F)(F)F)F
InChIKey:
KTBSXLIQKWEBRB-UHFFFAOYSA-N
PubChem:
53380437
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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