K145

K145 is an inhibitor of S1P Receptors and SK2 used in studies of GPCR Signaling and Metabolic Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to receptor-driven second-messenger signaling and desensitization dynamics and metabolic regulation, energy sensing, and enzyme-linked homeostasis in immunology, inflammation, and metabolism models.

By inhibiting S1P Receptors and SK2, K145 can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and metabolic regulation, energy sensing, and enzyme-linked homeostasis. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In immunology, inflammation, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

• Target-focused assays involving S1P Receptors and SK2
• Pathway perturbation studies connected to GPCR Signaling and Metabolic Signaling
• Concentration-response inhibition and target-dependence studies
• GPCR pharmacology, ligand-binding, and signaling assays

Overall, K145 is appropriate when a defined chemical perturbant is needed to connect S1P Receptors and SK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology, inflammation, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.