Ketanserin
Selleck Chemicals
SKU:S2232-100MG
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Ketanserin is an antagonist of 5-HT Receptors used in studies of GPCR Signaling and Neurotransmission. It is especially relevant in neuroscience models, where defined compound exposure can be linked to receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability.
By blocking 5-HT Receptors, Ketanserin can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In neuroscience models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving 5-HT Receptors
- Pathway perturbation studies connected to GPCR Signaling and Neurotransmission
- Receptor-blockade and ligand-competition studies
- GPCR pharmacology, ligand-binding, and signaling assays
Overall, Ketanserin is appropriate when a defined chemical perturbant is needed to connect 5-HT Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in neuroscience models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- 5-HT Receptors
- Target Class:
- GPCR
- Pathways:
- GPCR Signaling • Neurotransmission
- Research Area:
- Neuroscience
- CAS No.:
- 74050-98-9
- Molecular Weight:
- 395.43
- Formula:
- C₂₂H₂₂FN₃O₃
- SMILES:
- C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O
- InChIKey:
- FPCCSQOGAWCVBH-UHFFFAOYSA-N
- PubChem:
- 3822
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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