Laminin Receptor Antibody

About the Target

LAMININ-R is a target of interest in many antibody-based workflows. The 67 kDa high-affinity laminin receptor (67LR) is a non-integrin cell surface receptor primarily located in lipid rafts of the cell membrane, derived from the dimerization of the 37 kDa precursor (37LRP). While its main function is mediating cell adhesion, migration, proliferation, and survival by binding to laminin, 67LR also serves as a receptor for viruses, bacteria, prions, and epigallocatechin gallate (EGCG). Depending on the literature source, LAMININ-R may also be discussed as Laminin Receptor and 67kDa Laminin Receptor.

Reported cellular context includes cell membrane, cytoplasm, membrane, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following LAMININ-R across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

LAMININ-R is commonly interpreted in the context of cancer and infectious disease research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between cell membrane, cytoplasm, and membrane across matched conditions
• changes associated with proliferative state, oncogenic signaling, or treatment response
• host-response changes during infection or pathogen-associated stimulation
• co-patterning with orthogonal markers and control conditions that clarify pathway state

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for LAMININ-R. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in LAMININ-R reflect biology rather than handling. When interpreting LAMININ-R, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep LAMININ-R trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.